Pregabalin is a medication used world-wide in the treatment of partial onset seizures, postherpetic neuralgia, diabetic neuropathy, fibromyalgia, spinal cord injury neuropathic pain, and generalized anxiety disorder. The actions of pregabalin are mediated through binding with high affinity to alpha-2-delta proteins, which attenuates calcium influx into presynaptic neurons and thereby blocks the release of neurotransmitters, including the excitatory neurotransmitter l-glutamate.
| Package | Per pill | Total price | Save | Order |
|---|---|---|---|---|
| 150mg × 30 Pills | $1.96 | $58.66 + Bonus - 4 Pills | - | Add to cart |
| 150mg × 60 Pills | $1.56 | $93.70 + Bonus - 4 Pills | $24.00 | Add to cart |
| 150mg × 90 Pills | $1.54 | $138.20 + Bonus - 7 Pills | $37.80 | Add to cart |
| 150mg × 120 Pills | $1.51 | $181.10 + Bonus - 7 Pills | $54.00 | Add to cart |
| 150mg × 240 Pills | $1.40 | $336.93 + Bonus - 11 Pills Free Trackable Delivery | $134.40 | Add to cart |
| Package | Per pill | Total price | Save | Order |
|---|---|---|---|---|
| 75mg × 30 Pills | $1.36 | $40.65 + Bonus - 4 Pills | - | Add to cart |
| 75mg × 60 Pills | $1.10 | $65.70 + Bonus - 4 Pills | $15.60 | Add to cart |
| 75mg × 90 Pills | $1.06 | $95.20 + Bonus - 7 Pills | $27.00 | Add to cart |
| 75mg × 120 Pills | $1.00 | $120.10 + Bonus - 7 Pills | $43.20 | Add to cart |
| 75mg × 240 Pills | $0.92 | $221.93 + Bonus - 11 Pills Free Trackable Delivery | $105.60 | Add to cart |
Diabetes is a chronic condition that can lead to several complications, one of which is neuropathy. Neuropathy, or nerve damage, is a common complication that can affect people with diabetes and can lead to problems throughout the body. Diabetes can affect nerves that control movement, sensation, and other functions, leading to various symptoms and complications.
If you have diabetes, you can develop nerve problems at any time. Sometimes, neuropathy can be the first sign of diabetes. Significant nerve problems (clinical neuropathy) can develop within the first 10 years after a diabetes diagnosis. The risk of developing neuropathy increases the longer you have diabetes. About half of people with diabetes have some form of neuropathy.
Although the exact causes of diabetic neuropathy are unknown, several factors may contribute to the disorder. High blood sugar (glucose) is a significant contributor to neuropathy. High blood glucose causes chemical changes in nerves and impairs the nerves' ability to transmit signals. It can also damage blood vessels that carry oxygen and nutrients to the nerves.
Metabolic factors also play a role in the development of neuropathy. In addition to glucose levels, high triglyceride and cholesterol levels are also associated with increased risk of neuropathy. Patients who are overweight or obese are also at increased risk of developing neuropathy.
Inherited factors can also make some people more susceptible to nerve disease than others. Researchers have identified several genetic traits that may increase the risk of neuropathy.
Diabetic neuropathy can affect different nerves in the body, leading to different symptoms depending on the nerve affected. The most common type of diabetic neuropathy is peripheral neuropathy, which affects the feet and legs, leading to numbness, tingling, and pain. However, other types of neuropathy, known as focal neuropathy or mononeuropathy, can affect one nerve at a time, leading to various symptoms.
For example, focal neuropathy can affect nerves in the chest (thoracic nerves) and cause numbness and pain in the chest wall that mimics angina, heart attack, or appendicitis. Other types of focal neuropathy can cause pain in the thighs, severe pain in the lower back or pelvis, pain in the chest, stomach or flank, aching behind the eyes, inability to focus the eyes, double vision, paralysis on one side of the face, and hearing problems.
Preventing diabetic neuropathy involves good diabetes management, which includes maintaining healthy blood sugar levels, regular exercise, a healthy diet, and regular check-ups with your healthcare provider. If you experience any symptoms of neuropathy, such as numbness, tingling, or pain, it's essential to seek medical attention promptly to prevent further nerve damage.
In conclusion, diabetic neuropathy is a common complication of diabetes that can lead to problems throughout the body. Maintaining good diabetes management is crucial in preventing nerve damage and reducing the risk of neuropathy. If you experience any symptoms of neuropathy, seek medical attention promptly to prevent further nerve damage and maintain good health.